ea0084op-13-65 | Oral Session 13: Basic 3 | ETA2022
Giacco Antonia
, Petito Giuseppe
, Mercurio Giovanna
, Magnacca Nunzia
, Senese Rosalba
, Silvestri Elena
, Cioffi Federica
Objective: The maintenance of healthy and functional mitochondrial network via mitochondrial quality control (QC) mechanisms, is critical throughout life to respond to physiological adaptations and stress. Due to their role in energy production, mitochondria are exposed to high amounts of reactive oxygen species making their DNA (mtDNA) particularly vulnerable to oxidative damage. Mitochondrial dysfunction causes altered QC mechanisms (i.e. altered biogenesis, dynamics, autoph...